Great article, thanks! One typo: "no increase in the risk of Lewy body dementia", whereas Brennan and Tinworth 2025 found "higher odds of [...] Lewy body dementia (OR 1.32, 95% CI 1.23–1.41)". That's a lot!
Aside from the selection effects, there's also the possibility that having sex is good for you. If viagra makes people have better/more sex, it wouldn't be a huge surprise for that to show up as improved outcomes in weird places.
Honestly if these drugs improve people's sex lives, and they're well-tolerated, that's a good reason to use them anyway. There's no need to be squeamish about it or come up with some convoluted explanation about how it's "for Alzheimer's" - take the drugs that make your sex life better.
What is your take on MAO inhibitors like parnate and phenelzine? should everyone be on them regardless if they are depressed or not? they are the only ADs that haven shown to increase mood in "healthy" people
One of these standout features of humans is they don't seem to be able to spot what is important and relevant. Here we are trying to get the theory of everything and it will change absolutely everything and people are distracted by stubbed toes and shiny rocks.
It does seem on some kind of level that the monks are satire. Here we are getting the most extraordinary advanced science that is testable and our experts are admitting that they cannot explain 95% of the universe and our gurus like Richard Feynman are claiming that if you think you understand quantum mechanics then you do not understand quantum mechanics, yet this is what we listen to when the monks are giving us mystery after mystery after mystery explained and it's overwhelmingly obvious that they are correct and far more advanced than our science and therefore testable, yet even though this can save civilization we are so stupid that we'd rather have the wrong ideas. What does that say about us if you don't stand back and laugh at the stupidity of humanity?
Great article, thanks! One typo: "no increase in the risk of Lewy body dementia", whereas Brennan and Tinworth 2025 found "higher odds of [...] Lewy body dementia (OR 1.32, 95% CI 1.23–1.41)". That's a lot!
I'm referring to the PDE5A effect (OR = 0.99).
Aside from the selection effects, there's also the possibility that having sex is good for you. If viagra makes people have better/more sex, it wouldn't be a huge surprise for that to show up as improved outcomes in weird places.
Honestly if these drugs improve people's sex lives, and they're well-tolerated, that's a good reason to use them anyway. There's no need to be squeamish about it or come up with some convoluted explanation about how it's "for Alzheimer's" - take the drugs that make your sex life better.
What is your take on MAO inhibitors like parnate and phenelzine? should everyone be on them regardless if they are depressed or not? they are the only ADs that haven shown to increase mood in "healthy" people
One of these standout features of humans is they don't seem to be able to spot what is important and relevant. Here we are trying to get the theory of everything and it will change absolutely everything and people are distracted by stubbed toes and shiny rocks.
It does seem on some kind of level that the monks are satire. Here we are getting the most extraordinary advanced science that is testable and our experts are admitting that they cannot explain 95% of the universe and our gurus like Richard Feynman are claiming that if you think you understand quantum mechanics then you do not understand quantum mechanics, yet this is what we listen to when the monks are giving us mystery after mystery after mystery explained and it's overwhelmingly obvious that they are correct and far more advanced than our science and therefore testable, yet even though this can save civilization we are so stupid that we'd rather have the wrong ideas. What does that say about us if you don't stand back and laugh at the stupidity of humanity?