Regarding MIA, as best I understand their work, Hope et al. 2024 https://doi.org/10.1017/S0033291723003604 found no evidence of offspring neurodevelopment disorder (NDD) correlating with per-pregnancy maternal mental illness or infection with respect to siblings of the same mother whose pregnancy did not involve such illnesses. "these findings strongly imply that there is no specific link between maternal mental illness or maternal infection during pregnancy and subsequent risk of offspring NDD."
However, they did find correlations between such maternal illnesses and NDD in general. "Maternal risk appears to be unrelated to pregnancy: . . . " Regarding infections, they mention inflammation as a possible cause of poor neurodevelopment in utero.
Even if actual maternal illness in the specific pregnancy did not cause NDD in the child, it would generally be correlated with low 25-hydroxyvitamin D (see all the research cited and discussed at: https://vitamindstopscovid.info/00-evi/) in the mom-to-be and so in the fetus, whose brain is building itself.
As best I understand it, Lyndholm et al. 2018 https://sci-hub.se/10.1016/j.biopsych.2018.09.013 ("an earlier study of 1,206,600 Danish children") show both maternal and paternal infections correlating with offspring NDD. Since maternal and paternal 25-hydroxyvitamin D levels are likely to be highly correlated (use of multivitamins or proper vitamin D3 supplements, sun exposure, melanin content of skin), this is consistent with the hypothesis that parental infections are markers for (and in part the result of) low maternal 25-hydroxyvitamin D, and so are markers of low fetal and childhood 25-hydroxyvitamin D.
You wrote: "This evidence is strong enough to eliminate many of the proposed mechanisms that explain MIA. In fact, it’s strong enough to say that, as it’s typically specified, MIA just doesn’t seem to be true for humans." However, the pervasive effects of low 25-hydroxyvitamin D on infections and neurodevelopment are a mechanism which would explain the strong correlations found, though not on a specific pregnancy basis, between maternal infections and offspring NDD.
I don't think research in this field has been a waste. However, most researchers are clueless about the importance of good 25-hdroxyvitamin D levels for the immune system and neurodevelopment - though I am not sure that there are cell-level mechanisms known for the latter. Still, it is easy to see how 25-hydroxyvitamin D --> calcitriol intracrine signaling is used by many types of cell in addition to those in which it has been elucidated in detail: macrophages, dendritic cells and Th1 regulatory lymphocytes.
It's nice to have things we don't need to worry about, but are there studies that point to things mothers or aspiring mothers *can* do? It's all very well if genetics is 90% of the game, but we still have to make choices about the other 10%.
There is a correlation between epidurals and autism and an intersection between vaccinations and autism. Moms might just be able to affect a child's entire life span during the maternity process, including the development of the baby's personality, attributes, and characteristics of the child inside the womb.
If my tooth was numbed at the dentist and I bit down on my tongue immediately, I probably would still feel the bite if numbing medication wasn’t fully in my bloodstream. However, if I bite down on my tongue when the medication is entirely within my bloodstream, I probably won’t feel the bite.
Similarly, when a mom receives the epidural, she experiences instant relief. What is the baby experiencing? Could the child experience stress on the brain that can cause autism during the delivery process? How soon is too soon to receive the epidural before the baby is born? What if the mom receives the epidural when the child is in the birth canal and about to push out – what impact can that have on her baby's brain? Could the epidural be preventing the child’s natural ability to be born without causing stress on the brain? What stress, if any, can epidurals and pain medications have on the brain of the child during the natural delivery process? Can any other studies compare babies' brains during childbirth? Likewise, moms who use drugs while pregnant negatively impact their babies. In what ways can the epidural affect the baby’s brain when the experience is new to them inside the womb, never subjected too, during the entire pregnancy?
Part 1 Hypothesis: It is hypothesized that there is a negative relationship between the time when the mom receives the epidural and pain medication compared to when the baby is born, which can influence the chances of that baby having autism.
Childbirth is a phenomenon; nevertheless, the study should have included some other correlational variations, such as:
Could there be a correlation between the induced stress levels of the baby pushing out of the womb during natural birth and when the child receives a vaccination in epidural moms and non-epidural moms? Could vaccinations be given too soon to the baby, which causes stress on the brain, thus leading to autism? What correlations between autistic children and non-autistic children, if any, include times of vaccinations, epidurals, and pain medications that could influence autism?
Part 2 Hypothesis: It is hypothesized that babies who are vaccinated within 12 hours of being born have a higher rate of having autism compared to moms whose children are vaccinated after 12 hours of birth.
Part 3 Hypothesis: It is hypothesized that there is an interconnection between when a baby is born and how soon the mom receives epidural and pain medication, if any, and how soon the baby receives vaccinations after birth that can influence their chances of becoming autistic.
Comparing the control group to the placebo group of moms whose babies are not autistic is an excellent basis to begin—babies whose moms received epidurals and pain medications that did not produce autism. Are there any patterns in mom's health condition(s) that overlap in autistic births compared to normal births?
Part 4 Hypothesis: It is hypothesized that there is an impact of the health conditions with moms who receive epidurals and pain medication during delivery that can help determine the chances of their baby having autism.
Part 5 Hypothesis: It is hypothesized that moms with health conditions have a higher risk of their babies being autistic if they receive an epidural and pain medications.
When examining the centrality of the central part of moms having an eternal impact on the child during maternity, this must be examined from a spiritual perspective.
Here’s why….
God used this lady to ignite more ideas to me about how we were created. The Holy Spirit uses the entire body of Christ to help expand on his word. We as children of God always support the vision of God as a unit in one body as Christ being the Head of all of us.
People are like soil, and words (i.e., communication, songs, hymns, agreements, and disagreements) are the seeds planted within us. People produce a crop that sustains or produces a crop that dies Matthew 13. Moms are planting seeds within the baby before they are born. A baby has the personality, attributes, and characteristics created during their development inside the womb.
This is #revelation directly from God, the #righteous is like a #tree and a lion Proverbs 4:18; Proverbs 11:30; #Jeremiah 17:8; #Psalm 92:12-15; #Isaiah 9:6-7; #Proverbs 28:1; and Proverbs 13:12 #Amen
Are there any correlations between stressed moms and the impact on their babies when they are born?
A parent has a perception to pray to God, take medication, or live with mental health conditions with no treatment at all. Therefore, perception impacts the mom and her ability to influence her baby’s lifespan at maternity, affecting the baby throughout adulthood.
Part 6 Hypothesis: It is hypothesized that there is an effect on babies born to moms with spiritual beliefs and moms not spiritually inclined, which can impact their baby's ability to live healthy or unhealthy lifestyles into adulthood.
Part 7 Hypothesis: It is hypothesized that moms who eat healthily, communicate with their child in the womb (i.e., reading, singing, talking), and are in healthy relationships have children who produce stability, discipline, determination, and persistence.
I have not yet read all the above, but the words "nutrition" and "vitamin" do not appear. This is typically the case in medical discourse about a vast range of adverse health outcomes.
Please read the research on vitamin D and the immune system, cited and discussed at: https://vitamindstopscovid.info/00-evi/, especially https://vitamindstopscovid.info/00-evi/#3.2 which concerns low in-utero 25-hydroxyvitamin D levels causing (or strongly contributing to) autism, intellectual disability and other neurodevelopment disorders such as schizophrenia and ADHD. This section also concerns low birth weight and pre-eclampsia. .
The most important requirement of good health in general, especially for women of childbearing age - and so of moms-to-be and their babies - is proper vitamin D3 supplementation to attain at least the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin needed for full immune system function, and to support many other aspects of health, including neurodevelopment. There is no need for further research on this.
20 to 30 ng/mL (50 or 75 nmol/L) circulating 25-hydroxyvitamin D (made in the liver from vitamin D3 cholecalciferol by adding an OH hydroxyl group to the 25th carbon) is widely accepted as the threshold of sufficiency - but this is based on research into the kidney's ability to convert it to circulating calcitriol (1,25-dihydroxyvitamin D) to regulate calcium-phosphate-bone metabolism.
The real level of 25-hydroxyvitamin D sufficiency is ca. 50 ng/mL (125 nmol/L, 1 part in 20,000,000 by mass), as researchers and clinicians have been stating since 2008: https://www.grassrootshealth.net/project/our-scientists/ . The clearest evidence for this comes from research in Massachusetts General Hospital (Quraishi et al. 2014: https://sci-hub.se/10.1001/jamasurg.2013.3176) which shows increasing degrees of immune system failure the further below 125 nmol/L (50 ng/mL) the preoperative 25-hydroxyvitamin D level was. Post-operative infection risks were ca. 2.5% above this level and rose to 25% for about 45 nmol/L (18 ng/mL) pre-operative 25-hydroxyvitamin D.
Without proper vitamin D3 supplementation, such as 0.125 mg (5000 IU) a day for 70 kg body weight without obesity, or recent high level ultraviolet B exposure of ideally white skin (which damages DNA and raises the risk of skin cancer), many people have 20 ng/mL (50 nmol/L) or less 25-hydroxyvitamin D, so their immune system function is severely curtailed, for most or all their lives. People with dark or black skin have even lower levels, especially if they live far from the equator.
25-hydroxyvitamin D is needed as a raw input to be consumed by many types of immune cells (and other cell types involved in neurodevelopment) for their intracrine (inside each cell) signaling systems. Very few doctors or immunologists have heard of this signaling system, which was discovered in the mid-to-late 2000s. Neither vitamin D3 nor 25-hydroxyvitamin D are hormones - they are not signaling compounds. Calcitriol functions as a hormone (a long distance signaling molecule circulating in the bloodstream and perhaps cerebrospinal fluid) when it is produced by the kidneys. When it is produced, in response to the detection of a cell-type-specific condition, in intracrine signaling, the calcitriol acts as an intracrine agent, by altering the transcription of genes (and so the protein production and overall behaviour) of that individual cell. This is unrelated to hormonal signaling. The common statement that "vitamin D is a hormone" is completely incorrect. (Vieth 2004 https://sci-hub.se/10.1016/j.jsbmb.2004.03.037)
70 to 90 IU / kg body weight for those not suffering from obesity (BMI < 30).
100 to 130 IU / kg body weight for obesity I & II (BMI 30 to 39).
140 to 180 IU / kg body weight for obesity III (BMI > 39).
For 70 kg (154 lb) without obesity, this is about 0.125 milligrams (5000 IU) a day. This takes several months to attain the desired > 50 ng/mL circulating 25-hydroxyvitamin D. This is 8 or more times what most governments recommend. "5000 IU" sounds like a lot, but it is a gram every 22 years - and pharma grade vitamin D costs about USD$2.50 a gram ex-factory.
Thank you for dispassionately looking at all available studies, reporting sample sizes, and discussing confounding variables. Few people do this.
Regarding MIA, as best I understand their work, Hope et al. 2024 https://doi.org/10.1017/S0033291723003604 found no evidence of offspring neurodevelopment disorder (NDD) correlating with per-pregnancy maternal mental illness or infection with respect to siblings of the same mother whose pregnancy did not involve such illnesses. "these findings strongly imply that there is no specific link between maternal mental illness or maternal infection during pregnancy and subsequent risk of offspring NDD."
However, they did find correlations between such maternal illnesses and NDD in general. "Maternal risk appears to be unrelated to pregnancy: . . . " Regarding infections, they mention inflammation as a possible cause of poor neurodevelopment in utero.
Even if actual maternal illness in the specific pregnancy did not cause NDD in the child, it would generally be correlated with low 25-hydroxyvitamin D (see all the research cited and discussed at: https://vitamindstopscovid.info/00-evi/) in the mom-to-be and so in the fetus, whose brain is building itself.
As best I understand it, Lyndholm et al. 2018 https://sci-hub.se/10.1016/j.biopsych.2018.09.013 ("an earlier study of 1,206,600 Danish children") show both maternal and paternal infections correlating with offspring NDD. Since maternal and paternal 25-hydroxyvitamin D levels are likely to be highly correlated (use of multivitamins or proper vitamin D3 supplements, sun exposure, melanin content of skin), this is consistent with the hypothesis that parental infections are markers for (and in part the result of) low maternal 25-hydroxyvitamin D, and so are markers of low fetal and childhood 25-hydroxyvitamin D.
You wrote: "This evidence is strong enough to eliminate many of the proposed mechanisms that explain MIA. In fact, it’s strong enough to say that, as it’s typically specified, MIA just doesn’t seem to be true for humans." However, the pervasive effects of low 25-hydroxyvitamin D on infections and neurodevelopment are a mechanism which would explain the strong correlations found, though not on a specific pregnancy basis, between maternal infections and offspring NDD.
I don't think research in this field has been a waste. However, most researchers are clueless about the importance of good 25-hdroxyvitamin D levels for the immune system and neurodevelopment - though I am not sure that there are cell-level mechanisms known for the latter. Still, it is easy to see how 25-hydroxyvitamin D --> calcitriol intracrine signaling is used by many types of cell in addition to those in which it has been elucidated in detail: macrophages, dendritic cells and Th1 regulatory lymphocytes.
It's nice to have things we don't need to worry about, but are there studies that point to things mothers or aspiring mothers *can* do? It's all very well if genetics is 90% of the game, but we still have to make choices about the other 10%.
There is a correlation between epidurals and autism and an intersection between vaccinations and autism. Moms might just be able to affect a child's entire life span during the maternity process, including the development of the baby's personality, attributes, and characteristics of the child inside the womb.
If my tooth was numbed at the dentist and I bit down on my tongue immediately, I probably would still feel the bite if numbing medication wasn’t fully in my bloodstream. However, if I bite down on my tongue when the medication is entirely within my bloodstream, I probably won’t feel the bite.
Similarly, when a mom receives the epidural, she experiences instant relief. What is the baby experiencing? Could the child experience stress on the brain that can cause autism during the delivery process? How soon is too soon to receive the epidural before the baby is born? What if the mom receives the epidural when the child is in the birth canal and about to push out – what impact can that have on her baby's brain? Could the epidural be preventing the child’s natural ability to be born without causing stress on the brain? What stress, if any, can epidurals and pain medications have on the brain of the child during the natural delivery process? Can any other studies compare babies' brains during childbirth? Likewise, moms who use drugs while pregnant negatively impact their babies. In what ways can the epidural affect the baby’s brain when the experience is new to them inside the womb, never subjected too, during the entire pregnancy?
Part 1 Hypothesis: It is hypothesized that there is a negative relationship between the time when the mom receives the epidural and pain medication compared to when the baby is born, which can influence the chances of that baby having autism.
Childbirth is a phenomenon; nevertheless, the study should have included some other correlational variations, such as:
Could there be a correlation between the induced stress levels of the baby pushing out of the womb during natural birth and when the child receives a vaccination in epidural moms and non-epidural moms? Could vaccinations be given too soon to the baby, which causes stress on the brain, thus leading to autism? What correlations between autistic children and non-autistic children, if any, include times of vaccinations, epidurals, and pain medications that could influence autism?
Part 2 Hypothesis: It is hypothesized that babies who are vaccinated within 12 hours of being born have a higher rate of having autism compared to moms whose children are vaccinated after 12 hours of birth.
Part 3 Hypothesis: It is hypothesized that there is an interconnection between when a baby is born and how soon the mom receives epidural and pain medication, if any, and how soon the baby receives vaccinations after birth that can influence their chances of becoming autistic.
Comparing the control group to the placebo group of moms whose babies are not autistic is an excellent basis to begin—babies whose moms received epidurals and pain medications that did not produce autism. Are there any patterns in mom's health condition(s) that overlap in autistic births compared to normal births?
Part 4 Hypothesis: It is hypothesized that there is an impact of the health conditions with moms who receive epidurals and pain medication during delivery that can help determine the chances of their baby having autism.
Part 5 Hypothesis: It is hypothesized that moms with health conditions have a higher risk of their babies being autistic if they receive an epidural and pain medications.
When examining the centrality of the central part of moms having an eternal impact on the child during maternity, this must be examined from a spiritual perspective.
Here’s why….
God used this lady to ignite more ideas to me about how we were created. The Holy Spirit uses the entire body of Christ to help expand on his word. We as children of God always support the vision of God as a unit in one body as Christ being the Head of all of us.
Please look at this video.
https://fb.watch/pAgB4Xa_6f/
There are billions of neurons inside of the body that look like the root of a plant
https://duckduckgo.com/?q=billions+of+neurons+in+body&t=newext&atb=v408-1&ia=web
Heart vessels look like the root of a plant
https://duckduckgo.com/?q=the+heart+vessels+look+likke+the+root+of+a+plant&t=newext&atb=v408-1&iar=images&iax=images&ia=images
The systemic circulation of the heart looks like a cross.
https://duckduckgo.com/?q=systemic+circulation+of+the+heart&t=newext&atb=v408-1&iar=images&iax=images&ia=images
People are like soil, and words (i.e., communication, songs, hymns, agreements, and disagreements) are the seeds planted within us. People produce a crop that sustains or produces a crop that dies Matthew 13. Moms are planting seeds within the baby before they are born. A baby has the personality, attributes, and characteristics created during their development inside the womb.
This is #revelation directly from God, the #righteous is like a #tree and a lion Proverbs 4:18; Proverbs 11:30; #Jeremiah 17:8; #Psalm 92:12-15; #Isaiah 9:6-7; #Proverbs 28:1; and Proverbs 13:12 #Amen
Are there any correlations between stressed moms and the impact on their babies when they are born?
https://duckduckgo.com/?q=correlations+between+moms+that+are+stressed+and+the+impact+to+their+babies+when+they+are+born&t=newext&atb=v408-1&ia=web
High levels of maternal stress are linked to children’s mental health and behavior.
https://www.apa.org/news/press/releases/2023/11/maternal-stress-behavior-problems
It is safe to say that generational curses are formed during the maternal process when the baby is being developed in the womb.
https://duckduckgo.com/?q=generational+curses+are+formed+during+the+maternal+process+when+the+baby+is+being+developed+in+the+womb&t=newext&atb=v408-1&ia=web
A parent has a perception to pray to God, take medication, or live with mental health conditions with no treatment at all. Therefore, perception impacts the mom and her ability to influence her baby’s lifespan at maternity, affecting the baby throughout adulthood.
Part 6 Hypothesis: It is hypothesized that there is an effect on babies born to moms with spiritual beliefs and moms not spiritually inclined, which can impact their baby's ability to live healthy or unhealthy lifestyles into adulthood.
Part 7 Hypothesis: It is hypothesized that moms who eat healthily, communicate with their child in the womb (i.e., reading, singing, talking), and are in healthy relationships have children who produce stability, discipline, determination, and persistence.
I have not yet read all the above, but the words "nutrition" and "vitamin" do not appear. This is typically the case in medical discourse about a vast range of adverse health outcomes.
Please read the research on vitamin D and the immune system, cited and discussed at: https://vitamindstopscovid.info/00-evi/, especially https://vitamindstopscovid.info/00-evi/#3.2 which concerns low in-utero 25-hydroxyvitamin D levels causing (or strongly contributing to) autism, intellectual disability and other neurodevelopment disorders such as schizophrenia and ADHD. This section also concerns low birth weight and pre-eclampsia. .
The most important requirement of good health in general, especially for women of childbearing age - and so of moms-to-be and their babies - is proper vitamin D3 supplementation to attain at least the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin needed for full immune system function, and to support many other aspects of health, including neurodevelopment. There is no need for further research on this.
20 to 30 ng/mL (50 or 75 nmol/L) circulating 25-hydroxyvitamin D (made in the liver from vitamin D3 cholecalciferol by adding an OH hydroxyl group to the 25th carbon) is widely accepted as the threshold of sufficiency - but this is based on research into the kidney's ability to convert it to circulating calcitriol (1,25-dihydroxyvitamin D) to regulate calcium-phosphate-bone metabolism.
The real level of 25-hydroxyvitamin D sufficiency is ca. 50 ng/mL (125 nmol/L, 1 part in 20,000,000 by mass), as researchers and clinicians have been stating since 2008: https://www.grassrootshealth.net/project/our-scientists/ . The clearest evidence for this comes from research in Massachusetts General Hospital (Quraishi et al. 2014: https://sci-hub.se/10.1001/jamasurg.2013.3176) which shows increasing degrees of immune system failure the further below 125 nmol/L (50 ng/mL) the preoperative 25-hydroxyvitamin D level was. Post-operative infection risks were ca. 2.5% above this level and rose to 25% for about 45 nmol/L (18 ng/mL) pre-operative 25-hydroxyvitamin D.
Without proper vitamin D3 supplementation, such as 0.125 mg (5000 IU) a day for 70 kg body weight without obesity, or recent high level ultraviolet B exposure of ideally white skin (which damages DNA and raises the risk of skin cancer), many people have 20 ng/mL (50 nmol/L) or less 25-hydroxyvitamin D, so their immune system function is severely curtailed, for most or all their lives. People with dark or black skin have even lower levels, especially if they live far from the equator.
25-hydroxyvitamin D is needed as a raw input to be consumed by many types of immune cells (and other cell types involved in neurodevelopment) for their intracrine (inside each cell) signaling systems. Very few doctors or immunologists have heard of this signaling system, which was discovered in the mid-to-late 2000s. Neither vitamin D3 nor 25-hydroxyvitamin D are hormones - they are not signaling compounds. Calcitriol functions as a hormone (a long distance signaling molecule circulating in the bloodstream and perhaps cerebrospinal fluid) when it is produced by the kidneys. When it is produced, in response to the detection of a cell-type-specific condition, in intracrine signaling, the calcitriol acts as an intracrine agent, by altering the transcription of genes (and so the protein production and overall behaviour) of that individual cell. This is unrelated to hormonal signaling. The common statement that "vitamin D is a hormone" is completely incorrect. (Vieth 2004 https://sci-hub.se/10.1016/j.jsbmb.2004.03.037)
https://vitamindstopscovid.info/00-evi/#00-how-much includes Prof. Sunil Wimalawansa's recommendations https://www.mdpi.com/2072-6643/14/14/2997 for vitamin D3 supplemental intake to attain at least the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D, which the immune system needs to function properly. As he noted in a recent FLCCC webinar, these are ratios of body weight, with higher ratios for those suffering from obesity: https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/Weeekly_Webinar_Aug16_2023:d?t=3386 This is because people suffering from obesity convert less vitamin D3 into circulating 25-hydroxyvitamin D than normal-weight people.
The average daily vitamin D3 intake should be:
70 to 90 IU / kg body weight for those not suffering from obesity (BMI < 30).
100 to 130 IU / kg body weight for obesity I & II (BMI 30 to 39).
140 to 180 IU / kg body weight for obesity III (BMI > 39).
For 70 kg (154 lb) without obesity, this is about 0.125 milligrams (5000 IU) a day. This takes several months to attain the desired > 50 ng/mL circulating 25-hydroxyvitamin D. This is 8 or more times what most governments recommend. "5000 IU" sounds like a lot, but it is a gram every 22 years - and pharma grade vitamin D costs about USD$2.50 a gram ex-factory.
What sorts of literature? I haven't seen much to strongly indicate fecundability has declined.
I can't imagine you read this in the three minutes since it was posted.
Iodine and synthetic estrogens were in an initial draft but were ultimately removed.